The chart showing pdf series, word series, html series, scan qr codes. Primary neuroendocrine small cell carcinoma of the parotid. From 091991 062007, 24 highrisk salivary gland cancer patients were treated with surgery, followed by adjuvant chemoradiotherapy for highrisk pathologic features including, perineural involvement, nodal. Scc in the salivary glands is rare, comprising risk salivary gland malignancies treated with surgery followed by adjuvant chemoradiotherapy. This was an observational, analytical and longitudinal information reconstructed in time. Management of regional metastases of malignant salivary gland. The system proposed by auclair and goode is useful, and our data lend further support to its application and validity in clinical practice. Salivary duct carcinoma sdc is a rare type of aggressive cancer that arises from the salivary glands. Note the predominance of malignantappearing squamous cells.
Neville, 2002 mucoepidermoid carcinoma appears as asymptomatic swellings in minor salivary glands, being the second most common site of occurrence after the parotid gland, most commonly located on palate, followed by retromolar area, floor of mouth, buccal mucosa, lips, and tongue. Mucoepidermoid carcinoma the salivary glands are those glands whose primary function is to produce saliva. Clear cell carcinoma of minor salivary gland case report. Salivary glands are essential structures in the oral cavity. Ethics documents guidelines for the manuscript publishing process. Mucoepidermoid carcinoma of minor salivary gland in buccal. Mucoepidermoid carcinoma of intraoral salivary glands. More than half of these cases involve the major salivary glands, primarily the parotid glands.
Mucoepidermoid carcinoma can also be found in other organs, such. Mucoepidermoid carcinoma in children appears to follow a more favorable course with cure rates of 98100% ord 1994. Mucoepidermoid carcinoma high grade salivary glands. Salivary gland tumors sgt are rare neoplasms that generate interest due to their. It is slightly more common in women and the age range is 3rd to 7th. Most of these tumors are benign not cancer, but the parotid glands still are where most malignant cancerous salivary gland tumors start. These cases represented 19% of the total, and 4 1 yo of malignant, minor salivary gland neoplasms. Primary squamous cell carcinoma of submandibular salivary gland accounts to about 2%. Mucoepidermoid carcinoma mec is the most common malignant neoplasm of the major salivary glands, accounting for 15. The normally cuboidal ductal epithelial cells have been replaced by stratified squamous epithelium. It makes up about 30% of all malignant salivary gland tumors and about 10% to 15% of all salivary gland tumors. Malignant salivary tumors is a rare cancer that forms in tissues of salivary glands in the floor of the mouth and throughout the oropharynx, the parotid glands and the submandibular glands.
Minor salivary gland mucoepidermoid carcinoma in children. Salivary gland tumors are rare, and information on management of locoregional and metastatic disease is based. Squamous cell carcinoma of submandibular salivary gland. Salivary gland tumors tehran university of medical sciences. Pembrolizumab for the treatment of advanced salivary gland. These are the largest salivary glands and are found in front of and just below each ear. Clinicopathological analysis of salivary gland tumors over a 15year. Mucoepidermoid carcinoma is the most common type of minor salivary gland malignancy in adults. Sialolithiasis, adenoid cystic carcinoma, submandibular gland. Surgical treatment of the mucoepidermoid carcinoma of minor salivary gland origin is primarily a function of the anatomic site of the tumor and its histologic grade. Table of contents pdf file for saving and printing. An introduction to cytopathology is in the cytopathology article salivary gland cytopathology and salivary gland cytology redirect to here. A total of five malignant salivary gland tumors, all mecs, represented 1.
Mucoepidermoid carcinoma mec of the salivary gland is believed to arise from pluripotent reserve cells of the excretory ducts that are capable of differentiating into squamous, columnar, and mucous cells. Epithelial neoplasms originating in the minor salivary glands account for approximately 15% of all salivary gland neoplasms 6, 38. Figure 2 salivary gland, duct metaplasia, squamous in a male f344n rat from a chronic study higher magnification of figure 1. Mucoepidermoid carcinoma mec can have a variety of clinical outcomes, but prognosis seems to be related to the tumor grade. Of these, 143 cases qualified for inclusion in this study. Goode and corio reported nine cases of oncocytic carcinoma of the salivary glands, which they obtained from the files of the armed forces institute of pathology. Metastasis to the cervical lymph nodes is relative ly uncommon in carcinomas of the salivary glands.
A case report of coexistence of a sialolith and an adenoid cystic. The treatment may also depend upon the stage, overall health, age, and grade of the tumor. Mucoepidermoid carcinoma of the major salivary glands. The most common malignant salivary gland tumors include adenoid cystic carcinoma acc, mucoepidermoid carcinoma, secretory carcinomas, acinic cell carcinoma, and various adenocarcinoma histologies, including salivary ductal carcinoma. The aim of this study was to establish global survival rates and potential prognostic factors for mucoepidermoid carcinoma mc of the salivary glands in patients diagnosed at the dr. Adenosquamous cell carcinoma is a malignant tumour with the histological features of both adenocarcinoma and squamous cell carcinoma, but it is not listed as a salivary gland entity in the recent classification. Salivary gland carcinomas sgcs are rare, accounting for mucoepidermoid carcinoma of salivary gland treated. The following tumor types should not be reported using this protocol.
It is the most common malignant neoplasm observed in the major and minor salivary glands. Thyroid cancer long term salivary gland function in thyroid cancer survivors who received radioactive. Histocytologic grading of mucoepidermoid carcinoma of. The differential diagnosis includes metastatic squamous cell carcinoma. Cancer in the salivary gland is called salivary gland cancer. Mucoepidermoid carcinoma mec is the most common primary salivary gland malignancy, accounting for approximately 25% of all malignancies. Mucoepidermoid carcinoma mec is the most common malignant salivary gland tumor and it is the 2nd most common among all salivary gland tumors pleomorphic adenoma being the most common. Physiology, pathology and regeneration of salivary glands. It is predominantly seen in men and, generally, has a poor prognosis. Malignant salivary tumors rare cancer disabled world. Salivary glands may be affected by a number of diseases.
Mec can also involve a variety of other sites that have minor mucoserous glands. Salivary glands cancer, anaplastic small cell carcinoma of the salivary glands, adenosquamous carcinoma of the salivary glands, anaplastic. Figure 3 salivary gland, duct metaplasia, squamous in a. Fnac, histopathology, salivary glands lesions introduction fine needle aspiration cytology fnac is being increasingly used in the diagnosis of salivary gland lesions. Squamous cell carcinoma of salivary glands accounts for about 0. Physiology, pathology and regeneration of salivary glands mdpi.
The concept of dedifferentiation had previously been used in salivary gland carcinomas. It has been estimated that about 1% to 5% of all salivary gland tumors develop in children and adolescents 1, 8, and mec is the most common malignancy 5, 9, 39, 40. However, in the pediatric patient population, 50% of parotid gland tumors are malignant, but only 10% of submandibular gland tumors do. A variety of diseases, such as cancer, autoimmune diseases, infections and. Head and neck cytopathology is a small part of cytopathology. Cords, sheets and clusters of mucous, squamous, intermediate and clear cells. Table 1 world health organization 2005 classification of salivary gland tumors. Major salivary glands and some minor salivary glands are easily accessible. A combination of surgery, chemotherapy, and radiation therapy are used to treat mucoepidermoid carcinoma of salivary gland. Some investigators, however, include tumors of the airway seromu cous glands in discussions of salivary neoplasia because some tumors in these sites are. Longterm salivary gland function in thyroid cancer survivors who.
Neoplasms of salivary glands are rare in children, representing fewer than 10% of all pediatric head and neck tumors. Proliferating cell nuclear antigen expression in mucoepidermoid carcinoma of salivary glands. Most tumors of the minor salivary glands are malignant. A variety of diseases, such as cancer, autoimmune diseases, infections and physical. Mucoepidermoid carcinoma of the parotid gland in children. Minor salivary gland carcinoma consider the lip and oral cavity, nasal. Recently, the term highgrade transformation was introduced for adenoid cystic carcinoma, acinic cell carcinoma, epithelialmyoepithelial carcinoma, and polymorphous lowgrade adenocarcinoma and may better reflect this phenomenon, although transformation into moderately differentiated adenocarcinoma.
542 253 487 743 1388 232 636 1551 1567 1300 1581 1064 746 539 235 1055 1397 682 1535 755 1042 1054 1280 1413 1091 1235 799 328 23 1117 898 252 1424 1417 1423 752 654 1587 577 1459 1153 1187 154 28 1352 59 616 801 1422 386